Adverse Effects
The prominent adverse effects of antineoplastic drugs are exerted on rapidly proliferating normal tissues,
in addition, to their chronic and cumulative toxicities.
• Bone marrow toxicity: Bleomycin, L-asparaginase.
• Hair follicle toxicity: Methotrexate, Vincristine, Cyclophosphamide, and Doxoroubicin.
• Hepatotoxicity: Azathiopurine, Mercaptopurine, and L-asparaginase.
• Skin rashes: Vinca alkaloids, Nitrosourea, Anthracyclins, and Mitomycin C.
• Pulmonary toxicity: Bleomycin, Methotrexate, and Busulfan.
• Cardiac toxicity: Doxorubicin, Daunorubicin, and Anthracyclins.
• Other toxicities: Intestinal epithelium, central nervous system (CNS) toxicity, nephrotoxicity, immunosuppression, fever, anaphylaxis, cataracts, haemolytic anaemia, pancreatitis, pituitary insuffi ciency, adrenal insufficiency, coagulation problems, suppression of growth, and carcinogenicity
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